How Long to Read Immunogenic Cell Death in Cancer: From Benchside Research to Bedside Reality

How Long Does it Take to Read Immunogenic Cell Death in Cancer: From Benchside Research to Bedside Reality?

It takes the average reader 2 hours and 31 minutes to read Immunogenic Cell Death in Cancer: From Benchside Research to Bedside Reality by Abhishek D Garg

Assuming a reading speed of 250 words per minute. Learn more

Description

Classically, anti-cancer therapies have always been applied with the primary aim of tumor debulking achieved through widespread induction of cancer cell death. While the role of host immune system is frequently considered as host protective in various (antigen-bearing) pathologies or infections yet in case of cancer overtime it was proposed that the host immune system either plays no role in therapeutic efficacy or plays a limited role that is therapeutically unemployable. The concept that the immune system is dispensable for the efficacy of anticancer therapies lingered on for a substantial amount of time; not only because evidence supporting the claim that anti-cancer immunity played a role were mainly contradictory, but also largely because it was considered acceptable (and sometimes still is) to test anticancer therapies in immunodeficient mice (i.e. SCID/athymic mice lacking adaptive immune system). This latter practice played a detrimental role in appreciating the role of anticancer immunity in cancer therapy. This scenario is epitomized by the fact that for a long time the very existence of cancer-associated antigens or cancer-associated ‘danger signaling’ remained controversial. However, over last several years this dogmatic view has been considerably modified. The existence of cancer-associated antigens and ‘danger signaling’ has been proven to be incontrovertible. These developments have together paved way for the establishment of the attractive concept of “immunogenic cell death” (ICD). It has been established that a restricted class of chemotherapeutics/targeted therapeutics, radiotherapy, photodynamic therapy and certain oncolytic viruses can induce a form of cancer cell death called ICD which is accompanied by spatiotemporally defined emission of danger signals. These danger signals along with other factors help cancer cells undergoing ICD to activate host innate immune cells, which in turn activate T cell-based immunity that helps eradicate live (or residual) surviving cancer cells. The emergence of ICD has been marred by some controversy. ICD has been criticized to be either experimental model or setting-specific or mostly a concept based on rodent studies that may have very limited implications for clinical application. However, in recent times it has emerged (through mainly retrospective or prognostic studies) that ICD can work in various human clinical settings hinting towards clinical applicability of ICD. However a widespread consensus on this issue is still transitional. In the current Research Topic we aimed to organize and intensify a discussion that strives to bring together the academic and clinical research community in order to provide a background to the current state-of-the-art in ICD associated bench-side research and to initiate fruitful discussions on present and future prospects of ICD translating towards the clinical, bedside reality.

How long is Immunogenic Cell Death in Cancer: From Benchside Research to Bedside Reality?

Immunogenic Cell Death in Cancer: From Benchside Research to Bedside Reality by Abhishek D Garg is 147 pages long, and a total of 37,779 words.

This makes it 50% the length of the average book. It also has 46% more words than the average book.

How Long Does it Take to Read Immunogenic Cell Death in Cancer: From Benchside Research to Bedside Reality Aloud?

The average oral reading speed is 183 words per minute. This means it takes 3 hours and 26 minutes to read Immunogenic Cell Death in Cancer: From Benchside Research to Bedside Reality aloud.

What Reading Level is Immunogenic Cell Death in Cancer: From Benchside Research to Bedside Reality?

Immunogenic Cell Death in Cancer: From Benchside Research to Bedside Reality is suitable for students ages 10 and up.

Note that there may be other factors that effect this rating besides length that are not factored in on this page. This may include things like complex language or sensitive topics not suitable for students of certain ages.

When deciding what to show young students always use your best judgement and consult a professional.

Where Can I Buy Immunogenic Cell Death in Cancer: From Benchside Research to Bedside Reality?

Immunogenic Cell Death in Cancer: From Benchside Research to Bedside Reality by Abhishek D Garg is sold by several retailers and bookshops. However, Read Time works with Amazon to provide an easier way to purchase books.

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